Schizencephaly is an uncommon disorder of neuronal migrational characterized by a cerebrospinal fluid–filled cleft, which is lined by gray matter. The cleft extends across the entire cerebral hemisphere, from the ventricular surface (ependyma) to the periphery (pial surface) of the brain.
The clefts may be unilateral or bilateral and may be closed (fused lips), as in schizencephaly type I, or separated (open lips), as in schizencephaly type II.
Presentation and outcome are variable, but patients typically present with seizures, hemiparesis, and developmental deficits. Usually, the severity of symptoms is related to the amount of brain affected by the abnormality.
References:
1.Barkovich AJ, Norman D: MR imaging of schizencephaly. AJR Am J Roentgenol 1988 Jun; 150(6): 1391-6.
2.Barkovich AJ: Schizencephaly. In: Pediatric Neuroimaging. 2nd ed. Philadelphia: Lippincott-Raven; 1996:219-25.
3.Barth PG: Schizencephaly and nonlissencephalic cortical dysplasias. AJNR Am J Neuroradiol 1992 Jan-Feb; 13(1): 104-6
2 comments:
I don’t want people to feel sorry for me, that’s not why I am writing this post. My child six years ago, was born with Bi-lateral closed lip schizepcephaly, which is even more unique than the regular cases. Due to this disability, she also developed Cerebral Palsy affecting the left side of her body. We’ve learned the part of her brain which has been affected has also impaired her ability to reason. We’ve been lucky so far though it affects everyone differently and she had been on the very mild side of everything. Another thing we had to dealt with much are seizures. She was highly prone to having one or multiples and we’ve seemed to look out with some petite mals when she was younger and they occurred in her sleep more than any other time.
Luckily, everything seemed to be okay after she took an Herbal Medicine. I wish I could say that’s the end of it because she havn't had any symptoms since then.
Having a child with special needs is difficult. You sit living in fear of the reality your child may face, never really knowing what will happen until it does. Do not expose yourself to more danger, use a herbal remedy that is safe and effective. If interested contact him:
ronniemd70@gmail.com to find out more information about the disorder and treatment.
Nice Science Article.
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